IS OXYCODONE/NALOXONE EFFECTIVE AND SAFE IN MANAGING CHRONIC PAIN OF A FRAGILE ELDERLY PATIENT WITH MULTIPLE SKIN ULCERS OF THE LOWER LIMBS? A CASE REPORT 

Fabio Guerriero,1,2 Niccolo Maurizi,1 Matthew Francis,1 Carmelo Sgarlata,1 Giovanni Ricevuti,1,2 Mariangela Rondanelli,2,3 Simone Perna,2,3 Marco Rollone21Department of Internal Medicine and Medical Therapy, Section of Geriatrics, University of Pavia, 2Azienda di Servizi alla Persona, Istituto di Cura Santa Margherita The use of fractal t

Abstract Background Structural variations caused by a wide range of physico-chemical and biological sources directly influence the function of a protein.For enzymatic proteins, the structure and chemistry of the catalytic binding site residues can be loosely defined as a substructure of the protein.Comparative analysis of drug-receptor substructure